Losartan was more effective than atenolol for isolated systolic hypertension and left ventricular hypertrophy.

I n t e r v e n t i o n Patients were allocated to once-daily losartanbased therapy (n = 660) or atenolol-based therapy (n = 666) with hydrochlorothiazide as the second agent in both groups to reach a target systolic BP < 140 mm Hg. M a i n o u t c o m e m e a s u r e s A composite endpoint of cardiovascular mortality, myocardial infarction (MI), and stroke. Secondary outcomes included all-cause mortality and new-onset diabetes mellitus.